The most effective way to destroy a spell is to ensure it was never cast in the first place
Set: Zendikar Type: Basic Land — Swamp Rarity: Common ({T}: Add {B}
Set: Portal Three Kingdoms Type: Sorcery Rarity: Common Cost: {2}{W} Creatures you control get +1/+1 until end of turn
Set: Exodus Type: Creature — Spike Rarity: Uncommon Cost: {1}{B}{B} Spike Cannibal enters the battlefield with a +1/+1 counter on it
Tibalt Type: Creature — Nightmare Horror Rarity: Common Cost: {1}{B} When Mesmeric Fiend enters the battlefield
Kyoki, Sanity's Eclipse [Betrayers of Kamigawa] Dissension The most effective way toSet: Betrayers of Kamigawa Type: Legendary Creature Demon Spirit Rarity: Rare Cost: {4}{B}{B} Whenever you cast a Spirit or Arcane spell, target opponent exiles a card from their hand. "Kyoki, Eater of Minds, Corrupter of Thoughts, Bringer of Madness, Lord of Fear. Return, by our blood, and walk again." Ogre chant